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KMID : 0620720060120040214
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Natural Product Sciences
2006 Volume.12 No. 4 p.214 ~ p.216
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Anti-proliferation Effects of Isorhamnetin Isolated from Persicaria thunbergii on Cancer Cell Lines
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Lee Su-Kyung
Kwon Byoung-Mog
Baek Nam-In
Kim Sung-Hoon
Lee Jae-Hyeok
Park Hee-Wook
Kim Ju-Sin
Moon Mi-Kyeong
Kim Dae-Keun
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Abstract
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Isorhamnetin from the aerial parts of Persicaria thunbergii has been reported to have anti-tumor activity mediated by the inhibition of farnesyl protein transferase. In this study, we investigated the anti-proliferation effects of isorhamnetin on NIH3T3, K-RAS, H-RAS and SW620 cells, and it showed anti-proliferative effects in a dose-dependent manner with ICso value 4.1, 7.9, 20.2, and 22.4 ㎍/㎖, repectively.
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KEYWORD
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Isorhamnetin, Persicaria thunbergii, anti-proliferative activity
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