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KMID : 0620720060120040217
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Natural Product Sciences
2006 Volume.12 No. 4 p.217 ~ p.220
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Inhibition of Calcium Transport by (1R,9S)-β-Hydrastine Hydrochloride in PC12 Cells
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Yin Shou-Yu
Lee Myung-Koo
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Abstract
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The effects of (1R,9S)-β-Hydrastine Hydrochloride (BHSH) on Ca²+ ransport in rat pheochromocytoma PC12 cells were investigated. In the presence of external Ca²+, BHSH at 100μM inhibited K+ (56mM)-induced dopamine release, and K+ - induced Ca²+ influx and a sustained rise of [Ca²+]¡. In addition, BHSH at 100 f.!M reduced the sustained rise of [Ca²+]¡ elicited by 20 mM caffeine, but not by 1μM thapsigargin, in presence of external Ca²+. These results suggest that BHSH inhibited K+ - induced dopamine release and [Ca²+]¡ influx, and store-operated Ca²+ channels activated by caffeine, but not by thapsigargin, in PC12 cells.
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KEYWORD
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(1R, 9S)-β-Hydrastine Hydrochloride, K+ - induced dopamine release, caffeine-stimulated Ca²+ release, store-operated Ca²+ channel, PC12 cells
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