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KMID : 0620720070130010006
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Natural Product Sciences
2007 Volume.13 No. 1 p.6 ~ p.10
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Analgesic and Anti-inflammatory Activity of Carissa carandas Linn fruits and Microstylis wallichii Lindl Tubers
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Reddy G.D.
Kaushik Atul
Shanker K.
Tiwari R.K.
Mukherjee Alok
Rao Ch.V.
Sharma Alok
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Abstract
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The ethanolic (50% v/v) extracts of Carissa carandas (fruits) (Apocynaceae) and Microstylis wallichii (tubers) (Orchidaceae) were examined for anti-inflammatory and analgesic activities in experimental animals. Carissa carandas and Microstylis wallichii (50-200 mg/kg) caused a dose dependent inhibition of swelling caused by carrageenin significantly in cotton pellet induced granuloma in rats (P < 0.05 to P < 0.001). There was a significant increase in the analgesy meter induced pain in rats. The extracts of Carissa carandas and Microstylis wallichii resulted in an inhibition of stretching episodes and percentage protection was 16.05-17.58%respectively in acetic acid induced writhing.
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KEYWORD
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Carissa carandas, Microstylis wallichii, pain, inflammation
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