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KMID : 0620720070130010046
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Natural Product Sciences
2007 Volume.13 No. 1 p.46 ~ p.53
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Inhibitory Effect of Bacopa monniera on morphine Induced Pharmacological Effects in Mice
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Balakrishna K.
Veluchamy G.
Devaraj S. Niranjali
Sumathi T.
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Abstract
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The effects of the alcoholic extract of Bacopa monniera (BMA) on morphine-induced pharmacological activities were studied in mice. Oral administration of the extract (40 mg/kg) significantly inhibited morphine-induced analgesic tolerance, withdrawal symptoms, hyperactivity, reverse tolerance, Dopamine receptor supersensitivity and apo-morphine-induced climbing behaviour in mice. The results of this study showed that, alcoholic extract of Bacopa monniera (BMA) exerted inhibitory effect against morphine-induced pharmacological effects, suggesting that the extract could be useful in the treatment of morphine toxicity.
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KEYWORD
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Bacopa monniera, morphine toxicity, hyperactivity, analgesic tolerance, supersensitivity, climbing behaviour
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