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KMID : 0620720070130010054
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Natural Product Sciences
2007 Volume.13 No. 1 p.54 ~ p.60
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Antitumor Activity and Antioxidant Role of Ichnocarpus frutescens Against Ehrlich Ascites Carcinoma in Swiss Albino Mice
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Dash Deepak Kumar
Nayak Siva Shankar
Samanta Soma
Ghosh Tirtha
Jha Tarun
Maiti Bhim C
Maity Tapan K.
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Abstract
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The plant Ichnocarpus frutescens (Linn) R.Br. (Family-Apocynaceae) has been indicated for the treatment of various diseases, one amongst it is cancer. The purpose of this study was to investigate experimentally the possible antitumor activity and antioxidant role of Ichnocarpus frutescens in the mice transplanted with Ehrlich ascites carcinoma (EAC). The chloroform and methanol extract of whole plant of Ichnocarpus frutescens (CEIF and MEIF) were administered intraperitoneally at the dose of 150 mg/kg and 300 mg/kg, body weight per day for 7 days after 24 h of tumor inoculation in mice. Treatment with CEIF at the dose of 150 mg/kg and 300 mg/kg remarkably decreased the tumor volume, packed cell volume, viable cell count and increased the nonviable cell count of EAC tumor bearing mice when compared to e effect of MEIF at 150 mg/kg and 300 mg/kg. Further the EAC mice treated with CEIF and MEIF showed significant decrease in the level of lipid peroxidation and significant increase in the level of antioxidant enzymes such as glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT), however the decreasing and increasing capacity of CEIF was less in both doses as compared to MEIF. Based on these results, it can be concluded that the chloroform and methanol extact of Ichnocarpus frutescens exhibit significant antitumor and antioxidant activity in EAC bearing mice.
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KEYWORD
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Ichnocarpus frutescens, Ehrlich ascites carcinoma, antitumor activity, in vivo antioxidant activity
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