|
KMID : 0620720070130010061
|
|
Natural Product Sciences
2007 Volume.13 No. 1 p.61 ~ p.67
|
|
|
Hepatoprotective Activity of Ethanolic Extract of Bacopa monnieri Linn. Aerial Parts Against CCl₄- induced Hepatotoxicity in Rats
|
|
Maity Tapan Kumar
Dash Gouri Kumar
Bose Anindya
Nayak Siva Sankar
Dash Deepak Kumar
Ghosh Tirtha
|
|
|
Abstract
|
|
|
|
The ethanolic extract of Bacopa monnieri Linn. aerial parts were studied far its hepatoprotective effect on CCl₄- induced hepatotoxic rats. The extract was found to decrease significantly CCl₄- induced elevation of SGOT, SGPT, ALP, bilirubin and total cholesterol. But, it increased HDL-cholesterol level and liver weight with respect to CCl₄ toxic rats. The extract was also found to decrease significantly the CCl₄- induced elevation of lipid peroxidation and increase the activity of antioxidant enzymes (SOD and CAT) and GSH level in the liver of extract treated rats when compared with CCl₄ induced rats. Histopatholosical profiles showed that the extract had significant protective effect against CCl₄- induced liver injury, which corroborates the above findings. Hence it may be possible that the mechanism of hepatoprotection of the extract is due to its antioxidant effect.
|
|
|
KEYWORD
|
|
|
Bacopa monnieri L., ethanolic extract, hepatoprotective activity, antioxidant activity, histopathology
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|