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KMID : 0620720070130010078
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Natural Product Sciences
2007 Volume.13 No. 1 p.78 ~ p.84
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Administration of Aqueous Extract of Schizandra chinensis Fruit Inhibits the Experimental Colitis in Mice
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Kang Chon-Sik
Tae Jin
Ham Seong-Ho
Kim Dae-Ki
Lee Young-Mi
Lee Kang-Soo
Yun Yong-Gab
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Abstract
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Schizandra chinensis fruits (SC) have been used as a traditional Oriental medicine for treatments of many stress-induced diseases. In the present study, we investigated the protective effect of SC aqueous extract(SC-Ex) in the inflammatory diseases of intestine using a mouse model of ulcerative colitis. An experimental colitis was induced by daily treatment with 5% dextran sulfate sodium (DSS). SC-Ex was orally administered from day 2 of DSS treatment in a dose-dependent manner. Administration of SC-Ex reduced significantly clinic signs of DSS-induced colitis, including body weight loss, shorten colon length, increased disease activity index, and histological colon injury. Moreover, SC-Ex suppressed significantly not only the activities of myeloperoxidase (MPO) and chymase, but also the expressions of TNF-´a and COX-2 in DSS-treated colon tissues. Inhibitory effect of SC-Ex was effective at a dose over 20 mg/kg. Our results indicate that SC-Ex may possess therapeutic effect on the development of DSS-induced colitis.
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KEYWORD
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Schizandra chinensis, ulcerative colitis, colon injury, dextran sulfate sodium
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