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KMID : 0620720070130010090
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Natural Product Sciences
2007 Volume.13 No. 1 p.90 ~ p.96
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Polyketides from a Sponge-Derived Fungus, Aspergillus versicolor
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Lee Yoon-Mi
Mansoor Tayyab A.
Hong Jong-Ki
Lee Chong-Ock
Bae Kyung-Sook
Jung Jee-H.
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Abstract
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Bioactivity guided fractionation of the cultured filtrates of Aspergillus versicolor, which was derived from a marine sponge Petrosia sp., yielded three polyketides: decumbenones A (1),B (2), and versiol (3). These compounds were identified on the basis of 1D and 2D NMR spectroscopic and MS analysis. The absolute configuration was defined by the modified Mosher’s method. The isolated compounds were tested for cytotoxicity against a panel of five human solid tumor cell lines and antibacterial activity against twenty clinically isolated methicillin-resistant strains. This is the first report on the isolation of these compounds from a marine source.
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KEYWORD
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sponge-derived fungi, Aspergillus versicolor, polyketide, decumbenones A and B, versiol, Petrosia sp.
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