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KMID : 0620720070130020101
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Natural Product Sciences
2007 Volume.13 No. 2 p.101 ~ p.104
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Cytoprotective Activity of Belamcanda chinensis Rhizome Against Glutamate-Induced Oxidative Injury in HT22 Cells
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Jeong Gil-Saeng
An Ren-Bo
Oh Seung-Hwan
Kang Dae-Gill
Lee Ho-Sub
Kim Youn-Chul
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Abstract
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Four isoflavones including tectorigenin (1), irisflorentin (2), irigenin (3), and tectoridin (4) have been isolated from the 70% EtOH extract of Belamcanda chinensis rhizome. The evaluation for protective effect of compounds 1-4 against glutamate-induced cytotoxicity in hippocampal HT22 cell line was conducted. Compound 1 showed significant protective effect with an ECso value of 67.25 ± 1.2 μM, whereas compounds 2-4 were inactive. These results suggest that compound 1 may possess the neuroprotective activity against oxidative cellular injures.
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KEYWORD
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Tectorigenin, Isoflavone, belamcanda chinesis, glutamate-induced cytotoxicity, HT22 cells
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