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KMID : 0620720070130020118
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Natural Product Sciences
2007 Volume.13 No. 2 p.118 ~ p.122
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Cytoprotective Activity of Carpinus tschonoskii against HO Induced Oxidative Stress
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Zhang Rui
Kang Kyoung-Ah
Piao Mei Jing
Park Jae-Woo
Shin Taek-Yun
Yoo Byung-Sam
Yang Young-Taek
Hyun Jin-Won
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Abstract
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We have studied the cytoprotective effect on H2O2 induced oxidative stress from leaves of Carpinus tschonoskii. The methanol extract of Carpinus tschonoskii was found to scavenge intracellular reactive oxygen species (ROS) using flow cytometry and confocal microscope. This extract prevented lipid peroxidation and thus reduced cell death of Chinese hamster lung fibroblast (V79-4) induced by H2O2 treatment. The extract increased catalase activity and phosphorylation of extracellular signal regulated kinase (ERK). Taken together, the results suggest that Carpinus tschonoskii protects V79-4 cells against oxidative damage by H2O2 through scavenging ROS.
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KEYWORD
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oxidative stress, reactive oxygen species, Chinese hamster lung fibroblast, Carpinus tschonoskii
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