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KMID : 0620720070130020160
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Natural Product Sciences
2007 Volume.13 No. 2 p.160 ~ p.163
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An Ellagic Acid Rhamnoside from the Roots of Potentilla discolor with Protein Glycation and Rat Lens Aldose Reductase Inhibitory Activity
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Jang Dae-Sik
Yoo Nam-Hee
Kim Jong-Min
Lee Yun-Mi
Yoo Jeong-Lim
Kim Young-Sook
Kim Jin-Sook
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Abstract
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Four glycosides, rosamultin (1), tetracentronside B (2), 4-O-methylellagic acid 3-O-α-L-rhamnopyranoside (3), and vanillic acid 4-O-β-L-glucopyranoside (4), isolated from the roots extract of Potentilla discolor, were subjected to in vitro bioassays to evaluate the inhibitory activity on advanced glycation end products (AGEs) formation and rat lens aldose reductase (RLAR). Compound 3 exhibited a significant inhibitory activity against both AGEs formation and RLAR with ICso values of 79.5 and 8.03 μM, respectively. All the compounds (1-4) were isolated for the first time from this plant.
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KEYWORD
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Potentilla discolor, Rosaceae, diabetic complications, AGEs, aldose reductase
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