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KMID : 0620720070130030180
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Natural Product Sciences
2007 Volume.13 No. 3 p.180 ~ p.185
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Effect of Dichrostachys cinerea (Linn.) Root Extract on Ethylene Glycol Induced Urolithiasis in Rats
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Rao G. Srinivasa
Jayakumari S.
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Abstract
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Dichrostachys cinerea (Linn.) is commonly known as Vadatalla and used as phytotherapeutic agent. Tender shoots of the plant bruised and applied to the eyes in case of ophthalmia. The root is astringent and used in rheumatism, urinary calculi and renal troubles. The effect of the Ethanolic and aqueous extract of the root of D. cinerea were studied for its anti-urolithiatic and diuretic activity at 200 mg/kg dose level in male Wistar albino rats. Ethylene glycol feeding resulted in hyperoxaluria as well as increased renal excretion of calcium and phosphate. Supplementation with aqueous and ethanolic extract of the plant significantly reduced the elevated urinary oxalate, showing a regulatory action on endogenous oxalate synthesis. Compared to ethanolic extract, aqueous extract exhibited significant anti-urolithiatic activity. Both the extracts showed significant diuretic activity. The results of our present study supports folklore claim of D. cinerea.
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KEYWORD
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Dichrostachys cinerea, Urolithiasis, Ethylene glycol, Diuretic activity
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