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KMID : 0620720070130030251
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Natural Product Sciences
2007 Volume.13 No. 3 p.251 ~ p.254
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12,13-Dihydroxyfumitremorgin C, Fumitremorgin C, and Brevianamide F, Antibacterial Diketopiperazine Alkaloids from the Marine-Derived Fungus Pseudallescheria sp.
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Zhang Dahai
Noviendri Dedi
Nursid Muhammad
Yang Xiu-Dong
Son Byeng-Wha
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Abstract
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Dioxopiperazine alkaloids, 12R,13S-dihydroxyfumitremorgin C (1), fumitremorgin C (2), and brevianamide F (3), were isolated from the marine-derived fungus Pseudallescheria, and the absolute stereostructures of compounds 1 - 3 were elucidated on the basis of chemical and physicochemical evidence. Compounds 1 - 3 showed an antibacterial activity against Staphylococcus aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus. The MIC (minimum inhibitory concentration) values of compounds 1 - 3 were 125 μg/mL for all strains.
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KEYWORD
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Marine-derived fungus, Pseudallescheria sp., 12, 13-dihydroxyfumitremorgin C, fumitremorgin C, brevianamide F, antibacterial activity
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