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KMID : 0620720070130030263
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Natural Product Sciences
2007 Volume.13 No. 3 p.263 ~ p.267
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Small Black Soybean (Glycine max Merr.) Inhibits Mast Cell-mediated Allergic Reaction and Inflammatory Cytokine Secretion
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Shin Hye-Young
Lim Jong-Pil
Kim Dae-Keun
Chae Byeong-Suk
Kwon Young-Ee
Oh Chan-Ho
Cho Moon-Gu
Lee Tae-Gyu
Park Jeong-Suk
Lee Jae-Hyeok
Jeon Hoon
Shin Tae-Yong
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Abstract
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The mast cell-mediated immediate-type allergic reaction is involved in many allergic diseases such as asthma, allergic rhinitis, and sinusitis. The discovery of drugs for the treatment of mast cell-mediated immediatetype allergic diseases is a very important subject in human health. In this study, we investigated the effect of small black soybean (Glycine max Merr.) (Leguminosae) on mast cell-mediated allergic reaction and pro-inflammatory cytokine secretion. Small black soybean (SBS) inhibited compound 48/80-induced systemic reaction. SBS attenuated immunoglobulin (Ig) E-mediated local allergic reaction. In addition, SBS decreased the phorbol 12- myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-α and interleukin (IL)-8 secretion in human mast cells. These results indicate that SBS may be beneficial in the treatment of mast cell-mediated immediate-type allergic reactions.
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KEYWORD
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Small black soybean (Glycine max Merr.), Allergic reaction, Mast cells, Tumor necrosis factor (TNF)-α, Interleukin (IL)-8
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