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KMID : 0620720070130030268
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Natural Product Sciences
2007 Volume.13 No. 3 p.268 ~ p.271
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Cytoprotective Constituents of Alpinia katsumadai Seeds Against Glutamate-Induced Oxidative Injury in HT22 Cells
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Jeong Gil-Saeng
Li Bin
Lee Dong-Sung
Byun Erisa
Kang Dae-Gill
Lee Ho-Sub
Kim Youn-Chul
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Abstract
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Glutamate-induced oxidative injury contributes to neuronal degeneration in many central nervous system (CNS) diseases, such as epilepsy and ischemia. Bioassay-guided fractionation of the MeOH extract of the seeds of Alpinia katsumadai Hayata (Zingiberaceae) furnished three phenolic compounds, alpinetin (1), pinocembrin (2), and (+)-catechin (3). Compounds 2 and 3 showed the potent neuroprotective effects on glutamate-induced neurotoxicity and reactive oxygen species (ROS) generation in the mouse hippocampal HT22 cells. In addition, Compounds 2 and 3 showed significant DPPH free radical scavenging effect. These results suggest that compounds 2 and 3 could be the effective candidates for the treatment of ROS-related neurological diseases.
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KEYWORD
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Glutamate-induced toxicity, Alpinia katsumadai, HT22, DPPH, Cytoprotective
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