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KMID : 0620720070130040311
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Natural Product Sciences
2007 Volume.13 No. 4 p.311 ~ p.316
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[ α ]-Amylase and Protein Tyrosine Phosphatase 1B Inhibitory of Some Vietnamese Medicinal Plants Used to Treat Diabetes
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Hung Tran Manh
Manh Hoang-Duc
Minh Pham Thi Hong
Youn Ui-Joung
Na Min-Kyun
Oh Won-Keun
Min Byung-Sun
Bae Ki-Hwan
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Abstract
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In this study, the twenty-four ethyl acetate extracts of twenty-two medicinal plants, traditionally used in Vietnam as anti-diabetes agents, were investigated for -amylase and protein tyrosine phosphatase 1B (PTP1B) enzymes inhibitory activity in vitro. The results indicated that, twelve materials (50.0%) showed moderate to strong inhibitory activity in α-amylase inhibitory activity with ICso values ranging from 2.5 to 48.8 ㎍/mL ; meanwhile, ten extracts (41.6%) could demonstrate PTP1B activity with ICso values less than 30.5 ㎍/mL . Some plants presented interesting activities against both of -amylase and PTP1B enzymes such as Catharanthus roseus, Carthamus tinctorius, Momordica charantia, Gynostemma pentaphyllum, Glycyrrhiza glabra, Smilax glabra, Psidium guajava (leave), and Rehmannia glutinosa. The study may provide a proof, at least in a part, for the ethno-medical use in diabetes disease of these plants.
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KEYWORD
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Vietnamese medicinal plants, diabetes, α-amylase, protein tyrosine phosphatase 1B
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