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KMID : 0620720070130040328
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Natural Product Sciences
2007 Volume.13 No. 4 p.328 ~ p.331
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Farnesyl Protein Transferase Inhibitory Components of Lithospermum erythrorhizon
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Kim Seong-Jin
Kwon Byoung-Mog
Kim Sung-Hoon
Baek Nam-In
Yang Jae-Heon
Lee Jeong-Joo
Lee Sa-Im
Kwon Young-Ee
Park Hee-Wook
Lee Jae-Hyeok
Park Jeong-Suk
Kim Dae-Keun
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Abstract
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The methanolic extract of the roots of Lithospermum erythrorhizon (Boraginaceae) was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of three naphthoquinone compounds, as inhibitors of FPTase. These compounds inhibited the FPTase activity in a dose-dependent manner
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KEYWORD
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Lithospermum erythrorhizon, Boraginaceae, naphthoquinone, FPTase
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