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KMID : 0620720070130040337
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Natural Product Sciences
2007 Volume.13 No. 4 p.337 ~ p.341
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The Anti-allergic Effect of Vinegar Treated Small Black Soybean (Glycine max Merr.) is Mediated Through Inhibition of Histamine Release and Inflammatory Cytokine Secretion
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Shin Tae-Yong
Shin Hye-Young
Lim Jong-Pil
Jeon Hoon
Kim Dae-Keun
Chae Byeong-Suk
Kwon Young-Ee
Kang Sin-Myoung
Chang Ik-Jun
Park Jeong-Suk
Lee Jae-Hyeok
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Abstract
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In this report, we investigated the effect of aqueous extract of vinegar treated small black soybean (Glycine max Merr.) (Leguminosae) (VSBS) on mast cell-mediated allergic reaction and pro-inflammatory cytokine secretion. VSBS inhibited compound 48/80-induced systemic reactions. VSBS attenuated immunoglobulin (Ig) E-mediated passive cutaneous anaphylaxis. In addition, VSBS decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated secretion of tumor necrosis factor (TNF)-α, interleukin (IL)-6 and interleukin (IL)-8 in human mast cells. Our findings provide evidence that VSBS inhibits mast cell-derived allergic reactions.
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KEYWORD
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Glycine max Merr., allergic reaction, mast cells, tumor necrosis factor (TNF)-α, interleukin (IL)-6, interleukin (IL)-8
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