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KMID : 0620720070130040355
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Natural Product Sciences
2007 Volume.13 No. 4 p.355 ~ p.358
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Xylomaticin and Gonionenin, Cytotoxic Annonaceous Acetogenins from the Seeds of Annona cherimolia
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Kim Dal-Hwan
Fang Zhe
Lee Young-Eun
Woo Mi-Hee
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Abstract
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Further bioactivity-directed fractionation of the ethanol extract of the seeds of Annona cherimolia has led to the isolation of two mono-tetrahydrofuran acetogenins, xylomaticin (1) and gonionenin (2). The structures of these compounds were characterized on the basis of chemical and spectroscopic data. Compounds 1 and 2 have a relative stereochemistry relationship of threo/trans/threo across the mono-tetrahydrofuran ring with its two flanking hydroxyls. Compounds 1 and 2 are known, but are first isolated from this plant. In brine shrimp lethality test (BST), 1 and 2 exhibited cytotoxic activity.
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KEYWORD
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Annonaceous acetogenins, Annona cherimolia, xylomaticin, gonionenin, cytotoxic activity
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