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KMID : 0620720070130040359
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Natural Product Sciences
2007 Volume.13 No. 4 p.359 ~ p.364
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[ α ]-Amyrin Triterpenoids and Two Known Compounds with DNA Topoisomerase I Inhibitory Activity and Cytotoxicity from the Spikes of Prunella vulgaris var. lilacina
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Byun Soon-Jung
Fang Zhe
Jeong Su-Yang
Lee Chong-Soon
Son Jong-Keun
Woo Mi-Hee
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Abstract
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Three known α-amyrin triterpenoids, ursolic acid (1), 2α,3α-dihydro xyurs-12-ene-28-oic acid (2) and euscaphic acid (3), and β-amyrin triterpenoid, 3β-hydroxyolean-5,12-diene (4), and α-spinasterol (5) have been isolated from the fractionated n-butanol extracts of the spikes of Prunella vulgaris var. lilacina, guided by DNA topoisomerases I and II inhibitory activities and cytotoxic activity against human cancer cells. Their structures were elucidated on the basis of spectroscopic and chemical methods. Compound 4 exhibited significant cytotoxic activity against human colon adenoblastoma (HT-29), and 5 showed DNA topoisomerase I and II inhibitions.
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KEYWORD
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Prunella vulgaris var. lilacina, DNA topoisomerases I and II inhibitory activities, cytotoxic activity, ursolic acid, 2α, 3α-dihydroxyurs-12-ene-28-oic acid, euscaphic acid
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