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KMID : 0620720070130040369
Natural Product Sciences
2007 Volume.13 No. 4 p.369 ~ p.372
Protective Effect of Stilbenes on Oxidative Damage
Na Min-Kyun

Min Byung-Sun
Bae Ki-Hwan
Abstract
Oxidative stress induced by reactive oxygen species (ROS) has been suggested to be the cause of various degenerative diseases as well as aging. To evaluate the antioxidant potential of stilbenes, we have investigated the cytoprotective effect of 10 stilbenes derived from plants on the oxidative stress induced by tertiary butyl hydroperoxide (t-BuOOH). Of the stilbenes tested, piceatannol (3) showed the most potent activity, which was further investigated using an animal model. When 3 (30 or 10 mg/kg) was topically administered prior to UVB irradiation, the amount of the thiobarbituric acid reactive substances (TBARS) was significantly reduced compared to that of the control (vehicle). Our findings suggest that piceatannol is capable of protecting cells and tissues from oxidative stress.
KEYWORD
oxidative stress, stilbenes, tertiary butyl hydroperoxide, UVB irradiation, piceatannol, TBARS
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