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KMID : 0620720070130040384
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Natural Product Sciences
2007 Volume.13 No. 4 p.384 ~ p.389
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Inhibitory Effects of the Korean Red Ginseng Extract on the Content of Neurotransmitter-Related Components of the Mouse Brain in Convulsion-induced Model
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Choi Jong-Won
Yoo Yeong-Min
Park Hee-Juhn
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Abstract
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Treatment of mice with Korean Red Ginseng (KRG) changed glutamic acid and GABA content in the mouse brain tissue with pentylenetetrazole (PTZ)-induced convulsion. KRG were orally administered at a dose of 50, 100 mg/kg for two weeks. The electroconvulsions (MES) and PTZ-induced convulsion were reduced but those induced by strychnine, bicuculine and picrotoxin were not. PTZ-induced convulsion decreased the ~α-aminobutyric acid (GABA) content in brain compared to control group while the content was increased in KRG-treated group compared to PTZ group. In the PTZ-treated group, the GABA-transaminase (GABA-T) activity was increased by 59.6%, while no effect was observed on glutamate decarboxylase (GAD) activity. These results support that the KRG decreased the GABA contents and modulated the glutamic acid contents in the brain.
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KEYWORD
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Korean Red Ginseng (KRG), pentylenetetrazone (PTZ), GABA, GAD, GABA-T, glutamic acid
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