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KMID : 0620720080140010001
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Natural Product Sciences
2008 Volume.14 No. 1 p.1 ~ p.11
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Peroxynitrite scavengers from Phellinus linteus
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Jeong Da-Mi
Jung Hyun-Ah
Kang Hye-Sook
Choi Jae-Sue
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Abstract
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Peroxynitrite (ONOO￣ )is a cytotoxic species formed from nitric oxide and superoxide anion, which are highly implicated in the pathogenesis of oxidative stress-mediated diseases. The aim of this study was to investigate the scavenging effects of Phellinus linteus on authentic ONOO￣ , and further phytochemical studies are planned that will attempt to identify the active principles. From the active EtOAc fraction, a mixture of fungisterol and 5-dihydroergosterol (1), a mixture of betulin and 1,2-benzenedicarboxylic acid bis (2-methyl heptyl) ester (2), protocatechualdehyde (3), protocatechuic acid (4),cirsiumaldehyde (5), hispidin (6), caffeic acid (7), phelligridin D (8), uracil (9), gallic acid (10), 2,5-dihydroxybenzoic acid (11), ferulic acid (12), 2,3-dihydroxybenzaldehyde (13), arbutin (14), isoferulic acid (15), guanosine (16), and ellagic acid (17) were isolated, and their structures were characterized based on spectroscopic data. All compounds except 3, 6, 7 and 16 were isolated for the first time from P. linteus. Compounds 3, 4, 6-8, 10-15, and 17 showed potent scavenging activity on ONOO￣ , with ICso values of 2.06± 0.10, 3.45±0.57, 0.71±0.05, 2.78±0.36, 5.42±0.26, 1.13±0.02, 1.82±0.17, 0.91±0.19, 1.59±0.09, 1.88±0.07, 1.22±0.37 and 2.01±0.02㎼ , respectively, as compared to the positive control, DL-penicillamine, with an ICso value of 5.04±0.06 ㎼ .
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KEYWORD
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Phellinus linteus, peroxynitrite scavengers
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