|
KMID : 0620720080140010047
|
|
Natural Product Sciences
2008 Volume.14 No. 1 p.47 ~ p.50
|
|
|
Inhibitory Effect of Astragaloside I and IV on Passive Cutaneous Anaphylaxis Reaction and Scratching Behaviors in Mice
|
|
Han Sang-Jun
Bae Eun-Ah
Trinh Hien-Trung
Yang Jung-Hwa
Lee Eun-Ju
Kang Sam-Sik
Kim Dong-Hyun
|
|
|
Abstract
|
|
|
|
To evaluate the antiallergic effect of the dried root of Astragalus membranaceus Bunge (AM) (Leguminosae), which inhibited the mouse passive cutaneous anaphylaxis (PCA) reaction in a preliminary experiment, its main constituents, astragalosides I and IV, were isolated and their antiallergic effects were investigated. Astragalosides I and IV inhibited the PCA reaction induced by the IgE-antigen complex, and the scratching behaviors induced by compound 48/80. These constituents reduced the protein expressions of TNF-α and IL-4 in IgE-induced RBL-2H3 cells. These findings suggest that astragalosides I and IV as well as AM can improve IgE-induced anaphylaxis and scratching behaviors.
|
|
|
KEYWORD
|
|
|
Astragalus membranaceus, astragaloside, allergy, anaphylaxis, itching
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|