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KMID : 0620720080140010056
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Natural Product Sciences
2008 Volume.14 No. 1 p.56 ~ p.61
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Bioactivity Guided Phytochemical Study of Clematis hirsuta Growing in Saudi Arabia
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Al-Taweel Areej M.
El-Deeb Kadriya S.
Abdel-Kader Maged S.
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Abstract
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Bioactivity guided phytochemical study of the petroleum ether and butanol extracts of Clematis hirsuta resulted in the isolation of 12 compounds. Rat paw edema as a model of acute inflammation was used to evaluate the anti-inflammatory activity of the extracts and the chromatographic fractions. Five known sterols and triterpenes namely: β-amyrin (1), lupeol (2), β-sitosterol (3), oleanolic acid (4) and stigmasterol glycoside (5) were isolated from the petroleum ether extract. The n-butanol extract afforded two compounds reported for the first time from natural source: (S)-(+)-dihydro-5-(hydroxymethyl)-2(3H)-furanone (7) and (s)-(-)-5-hydroxymethyl-2(5H)-furanone (8). In addition, anemonin (6), dihydro-4-hydroxy-5-(hydroxymethyl)-2(3H)-furanone (2-deoxy-D-ribono-1,4-lactone) (9), biophenol (cimidahurin) (10), glucose (11) and sucrose (12) were also identified. The structures were determined from spectroscopic data including 1D- and 2D-NMR experiments.
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KEYWORD
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Clematis hirsuta, triterpenes, sterols, anemonin, anti-inflammatory
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