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KMID : 0620720080140020090
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Natural Product Sciences
2008 Volume.14 No. 2 p.90 ~ p.94
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Cytotoxic Compounds from the Stem Bark of Magnolia obovata
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Min Byung-Sun
Bae Ki-Hwan
Youn Ui-Joung
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Abstract
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Two sesquiterpenes (1 - 2), a tetralone (3), and two phenylpropanoids (4 - 5) were isolated from the stem bark of Magnolia obovata Thunberg (Magnoliaceae) through repeated column chromatography. Their structures were identified as (1), cryptomeridiol (2), 4R-4,8-dihydroxy- (3), trans-pcoumaryl aldehyde (4), and p-coumaric acid (5) on the basis of spectroscopic analysis including two dimensional NMR and mass. Compounds 1 - 3 were tested in vitro for their cytotoxic activity against the K562, HeLa, A549, and HCT116 cancer cell lines. However, compounds 1 - 3 were inactive in this assay system.
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KEYWORD
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Magnolia obovata, Magnoliaceae, sesquiterpene, tetralone, cytotoxic activity
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