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KMID : 0620720080140020107
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Natural Product Sciences
2008 Volume.14 No. 2 p.107 ~ p.112
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Antioxidant Activities of Phenolic Derivatives from Dipsacus asper Wall. (II)
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Hung Tran Manh
Bae Ki-Hwan
Min Byung-Sun
Thuong Phuong Thien
Youn Ui-Joung
Woo Mi-Hee
Lee Hyeong-Kyu
Zhang Xin Feng
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Abstract
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The six phenolic compounds isolated from the root of Dipsacus asper, 3,4-di-O-caffeoylquinic acid (1), methyl 3,4-di-O-caffeoyl quinate (2), 3,5-di-O-caffeoylquinic acid (3), methyl 3,5-di-O-caffeoyl quinate (4), 4-5-di-O-caffeoylquinic acid (5), methyl 4,5-di-O-caffeoyl quinate (6) were continuously evaluated for their antioxidant activity using superoxide radical scavenging and AAPH-mediated (LDL) oxidation assay. The results demonstrated that compounds 1 - 6 had remarkable antioxidant activities with the values ranging from 12.0 to in superoxide radical scavenging. They also inhibited AAPH-mediated low-density lipoprotein LDL oxidation by the generation of thiobarbituric acid reactive substances (TBARS) with ranging from 6.7 to
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KEYWORD
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Dipsacus asper, Dipsacaceae, phenolic, superroxide radical scavenging, low-density lipoprotein
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