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KMID : 0620720080140020127
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Natural Product Sciences
2008 Volume.14 No. 2 p.127 ~ p.130
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Radical Scavenging Effects and Protective Effect of Spatholobus suberectus against Liver Damage in Rats
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Jeon Hoon
Kim Dae-Keun
Shin Tae-Yong
Lim Jong-Pil
Kim Sung-Zoo
Bu Young-Min
Eun Jae-Soon
Yang Jae-Heon
Oh Chan-Ho
Cha Dong-Seok
Park Ho-Jun
Lee Yong-Jae
Lee Se-Youn
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Abstract
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In the present study, we obtained an extract from the dried stem of Spatholobus suberectus Dunn by using 85% methanol (MeOH extract of S. suberectus; MSS) and investigated its radical scavenging effects in vitro and its protective effect against liver damage in rats. MSS scavenged the 1,1-diphenyl-2- picrylhydrazyl radical almost completely and inhibited lipid peroxidation (LPO) in the liver homogenate. Oral administration of MSS significantly reduced the serum glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, and alkaline phosphatase and inhibited LPO in the liver tissue after treatment in rats. These results suggest that S. suberectus could be a candidate agent for the treatment of diseases related to oxidative stress.
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KEYWORD
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Spatholobus suberectus, carbon tetrachloride, free radical, lipid peroxidation, antioxidant effect
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