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KMID : 0620720080140020143
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Natural Product Sciences
2008 Volume.14 No. 2 p.143 ~ p.146
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Protein Tyrosine Phosphatase 1B inhibitory Activity of Anthraquinones and Stilbenes
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Na Min-Kyun
Bae Ki-Hwan
Ahn Jong-Seog
Min Byung-Sun
Jin Wen-Yi
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Abstract
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Protein tyrosine phosphatase 1B (PTP1B) is emerging as a potential therapeutic target for the treatment of type-2 diabetes and obesity. To search for new types of PTP1B inhibitors, we have undertaken in vitro enzyme assay for some anthraquinones and stilbenes isolated from plants. Of the anthraquinones tested, physcion (1), 1-O-methylemodin (2), and emodin (3) showed high activities, with values of 7.6, 7.0, and , respectively, while the anthraquinone glycosides, physcion-8-O--D-glucopyranoside (4) and emodin-8- O--D-glucopyranoside (5), were less active than their aglycones. All the stilbenens (6 - 15) slightly inhibited PTP1B activity at high concentration of . Our findings suggest that the hypoglycemic effect of anthraquinones may be associated with their PTP1B inhibitory activity.
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KEYWORD
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Protein tyrosine phosphatase 1B (PTP1B), anthraquinones, stilbenes, in vitro enzyme assay
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