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KMID : 0620720080140030192
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Natural Product Sciences
2008 Volume.14 No. 3 p.192 ~ p.195
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Puerarol from the Roots of Pueraria Lobata Inhibits the Formation of Advanced Glycation End Products (AGEs) in vitro
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Kim Jong-Min
Jang Dae-Sik
Lee Yun-Mi
Kim Young-Sook
Kim Jin-Sook
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Abstract
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Three known compounds, puerarol (1), pueroside B (2), and ononin (3), were isolated from an EtOAc-soluble fraction of the roots of Pueraria lobata. The isolates (1 - 3) were subjected to an in vitro bioassay to evaluate their inhibitory activity on the formation of advanced glycation end products (AGEs). Puerarol (1) exhibited a remarkable inhibitory activity on AGEs formation with IC50 value of 2.05 ± 0.32 μM as compared with positive control, aminoguanidine (IC50 value : 905.32 ± 7.58 μM).
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KEYWORD
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Pueraria Lobata, Leguminosae, puerarol, advanced glycation end products, AGEs, diabetic complications
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