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KMID : 0620720080140040249
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Natural Product Sciences
2008 Volume.14 No. 4 p.249 ~ p.253
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Anti-complement Activity of Triterpenoids from the Whole Plant of Patrinia saniculaefolia
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An Ren-Bo
Na Min-Kyun
Min Byung-Sun
Lee Hyeong-Kyu
Bae Ki-Hwan
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Abstract
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Two oleanane-type triterpenes (1, 2) and their glycosides (4-6), and one ursane-type triterpene (3) have been isolated from a methanolic extract of Patrinia saniculaefolia Hemsley (Valerianaceae) through repeated silica gel and reversed-phase C-18 column chromatography. Their chemical structures were determined as oleanolic acid (1), oleanonic acid (2), 23-hydroxyursolic acid (3), 3-O--L-arabinopyranosyl-oleanolic acid (4), 3-O--D-glucopyranosyl-oleanolic acid (5), and oleanolic acid 3-O-[-D-xylopyranosyl-()--D-glucuronopyranoside-6-O-butyl-ester] (6) on the basis of their MS, -, and -NMR spectral data. All compounds were isolated from the whole plant of the P. saniculaefolia for the first time. These compounds were examined for their anti-complement activity against the classical pathway of the complement system. Among them, compounds 1 - 3 exhibited anti-complement activity with values of 470.1, 212.2, and 121.0 , respectively, whereas compounds 4 - 6 were inactive. These results suggest that the carbonyl or hydroxy group at C-3 in the oleananeand/or ursane-triterpenes are important for the anti-complement activity against the classical pathway.
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KEYWORD
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Patrinia saniculaefolia, Valerianaceae, 23-hydroxyursolic acid, anti-complement activity
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