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KMID : 0620720090150010022
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Natural Product Sciences
2009 Volume.15 No. 1 p.22 ~ p.26
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A New Naphthoquinone with Anti-inflammatory Activity from An Egyptian Collection of Echiochilon fruticosum
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Fathy Hoda M.
Aboushoer Mohamed I.
Baraka Azza
Abdel-Kader Maged S.
Omar Abdallah A.
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Abstract
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Phytochemical investigation of the roots of Echiochilon fruticosum resulted in the isolation of two naphthoquinone derivatives. Compound 1 was identified as anhydroalkanin while compound 2 was identified as a new derivative 5-hydroxy 8-methoxy 2-(4-methylpent-1,3-dienyl) naphthalene-1,4-dione named as echiochiloquinone. In addition, caffeic acid 3, caffeic acid methyl ester 4 were isolated. The structures were determined by physical, chemical and spectral methods. The anti-inflammatory activity of the root extracts and compound 2 was evaluated utilizing both cotton pellet-induced and carragenin-induced rat paw edema. The ulcerogenic effect was also studied.
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KEYWORD
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Echiochilon fruticosum, Naphthoquinones, Echiochiloquinone, Caffeic acid, Anti-inflammatory, Ulcerogenic
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