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KMID : 0620720090150020090
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Natural Product Sciences
2009 Volume.15 No. 2 p.90 ~ p.95
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Phytochemical Constituents of Nelumbo nucifera
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Kim Ki-Hyun
Chang Sang-Wook
Ryu Shi-Yong
Choi Sang-Un
Lee Kang-Ro
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Abstract
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Phytochemical investigation of the MeOH extract of the leaves of Nelumbo nucifera resulted in the isolation of five norsesquiterpenes, four flavonoids, two triterpenes and one alkaloid. Their chemical structures were characterized by spectroscopic methods to be (E)-3-hydroxymegastigm-7-en-9-one (1), (3S,5R,6S,7E)- megastigma-7-ene-3,5,6,9-tetrol (2), dendranthemoside B (3), icariside (4), sedumoside (5), luteolin (6), quercetin 3-0--D-glucuronide (7), quercetin 3-0--D-glucoside (8), isorhamnetin 3-0-rutinoside (9), alphitolic acid (10), maslinic acid (11), and N-methylasimilobine (12). Norsesquiterpenoids (1-5) and triterpenes (10-11) were isolated for the first time from this plant. Compounds 6 and 10-12 exhibited considerable cytotoxicity against four human cancer cell lines in vitro using a SRB bioassay.
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KEYWORD
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Nelumbo nucifera, Nymphaeaceae, Norsesquiterpenes, Cytotoxicity
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