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KMID : 0620720090150030130
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Natural Product Sciences
2009 Volume.15 No. 3 p.130 ~ p.133
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An Acetophenone Derivative, Clavatol, and a Benzodiazepine Alkaloid, Circumdatin A, from the Marine-Derived Fungus Cladosporium
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Yang Guo-Hua
Kang Jung-Sook
Son Byeng-Wha
Nenkep Viviane N.
Siwe-Noundou Xavier
Leutou Alain S.
Feng Zhile
Zhang Dahai
Choi Hong-Dae
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Abstract
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The crude extract of the mycelium of Cladosporium was found to exhibit antimicrobial activity against the Staphylococcus aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus. Bioassayguided fractionation of an organic extract led to the isolation of an acetophenone derivative, clavatol (2’,4’-dihydroxy-3’,5’-dimethylacetophenone) (1), and a benzodiazepine alkaloid, circumdatin A (2). Compound 1 showed moderate antibacterial activity against S. aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus with minimum inhibitory concentration (MIC) values of 62.5, 62.5, 31.0 g/mL, respectively, but compound 2 was inactive. Compounds 1 and 2 exhibited UV-A protection activity with ED values of 227.0 and 82.0 M, respectively, indicating that they were more potent than the positive control, oxybenzone (ED 350 M), a common sunscreen agent.
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KEYWORD
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Cladosporium sp., Acetophenone, Clavatol, Benzodiazepine alkaloid, Circumdatin A
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