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KMID : 0620720090150030151
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Natural Product Sciences
2009 Volume.15 No. 3 p.151 ~ p.155
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Phytochemical Constituents of Geranium eriostemon
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Chang Sang-Wook
Kim Ki-Hyun
Lee Il-Kyun
Choi Sang-Un
Lee Kang-Ro
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Abstract
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Phytochemical investigation of the MeOH extract of the aerial parts of Geranium eriostemon resulted in the isolation of one triterpene, three furofuran lignans, one syringic acid and four flavonoids. Their chemical structures were characterized by spectroscopic methods to be oleanolic acid (1), (-)-kobusin (2), (-)-eudesmin (3), (+)-magnolin (4), syringic acid (5), quercetin (6), juglanin (7), juglalin (8), and hyperin (9). All compounds (1 - 9) were isolated for the first time from this plant source and the compounds 2 - 4 were reported first from the genus Geranium. Compounds 4 - 6 exhibited moderate cytotoxicity against four human cancer cell lines in vitro using a SRB bioassay.
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KEYWORD
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Geranium eriostemon, Geraniaceae, Lignan, Cytotoxicity
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