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KMID : 0620720090150030162
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Natural Product Sciences
2009 Volume.15 No. 3 p.162 ~ p.166
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Protective Effect of Extracts from Euryale ferox against Glutamate-induced Cytotoxicity in Neuronal Cells
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Lee Mi-Ra
Kim Ji-Hyun
Son Eun-Soon
Park Hae-Ryong
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Abstract
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Oxczaasssaidative stress plays an important role in neuronal cell death, which is associated with neurodegenerative conditions such as Alzheimer’s and Parkinson’s disease. This study evaluated the neuroprotective effect of Euryale ferox (EF) extracts against glutamate-induced cytotoxicity in hybridoma N18-RE-105 cells. Specifically, neuroprotective effects of methanol and ethanol extracts were evaluated by the MTT reduction assay. The ethanol extracts of EF displayed dose dependent protection against neuronal cell death induced by 20 mM of glutamate. Furthermore, the ethanol extracts of EF was sequentially fractionated with hexane, diethyl ether, ethyl acetate, and water layer according to degree of polarity. The hexane fractions exhibited neuroprotective effect against glutamate-stressed N18-RE-105 cells. Overall, results suggest that EF extracts can potentially be used as chemotherapeutic agents against neuronal diseases.
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KEYWORD
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Oxidative stress, Neuroprotective, Euryale ferox, Glutamate, N18-RE-105 cells
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