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KMID : 0620720090150040192
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Natural Product Sciences
2009 Volume.15 No. 4 p.192 ~ p.197
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Chemical Constituents from Artemisia iwayomogi Increase the Function of Osteoblastic MC3T3-E1 Cells
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Ding Yan
Liang Chun
Choi Eun-Mi
Ra Jeong-Chan
Kim Young-Ho
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Abstract
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Chemical investigation of the aerial parts of Artemisia iwayomogi has afforded five glycoside compounds. Their chemical structures were characterized by spectroscopic methods to be turpinionoside A (1), (Z)-3-hexenyl O-α-arabinopyranosyl-(1→ 6)-O-β-D-glucopyranoside (2), (Z)-5’-hydroxyjasmone 5’-O-β-Dglucopyranoside (3), (?)-syringaresinol-4-O-β-D-glucopyranoside (4), and methyl 3,5-di-O-caffeoyl quinate (5). All of them were isolated for the first time from Artemisia species. The effect of compounds 1 - 5 on the function of osteoblastic MC3T3-E1 cells was examined by checking the cell viability, alkaline phosphatase (ALP) activity, collagen synthesis, and mineralization. Turpinionoside A (1) significantly increased the function of osteoblastic MC3T3-E1 cells. Cell viability, ALP activity, collagen synthesis, and mineralization were increased up to 117.2% (2 μM), 110.7% (0.4 μM), 156.0% (0.4 μM), and 143.0 % (2 μM), respectively.
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KEYWORD
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Artemisia iwayomogi, Glycoside compounds, Osteoblastic MC3T3-E1 cells
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