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KMID : 0620720090150040198
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Natural Product Sciences
2009 Volume.15 No. 4 p.198 ~ p.202
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Effects of α-Asarone against Global Cerebral Ischemia in Rats
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Kim Young-Ock
Kwon Yong-Soo
Lee Seong-Eun
Lee Sang-Won
Lee Hee-Jae
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Abstract
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Based on the use of Acorus gramineus SOLAND (AG) for the treatment of stroke in traditional Korean medicine, the present study was carried out to evaluate neuroprotective effects of α-asarone after transient global cerebral ischemia using rat 4-vessel occlusion (4VO) model in rats. α-Asarone (5 mg/kg) administered intraperitoneally significantly protected CA1 neurons against 10 min transient forebrain ischemia as demonstrated by measuring the density of neuronal cells stained with Cresyl violet. α-Asarone significantly reduced hippocampal neuronal cell death by 85.2% where as its isolated single compounds from AG compared with a vehicle-treated group.
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KEYWORD
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Stroke, Neuroprotective, α-Asarone, Global cerebral ischemia
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