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KMID : 0620720090150040234
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Natural Product Sciences
2009 Volume.15 No. 4 p.234 ~ p.240
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Phytochemical Constituents of Bistorta manshuriensis
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Chang Sang-Wook
Kim Ki-Hyun
Lee Il-Kyun
Choi Sang-Un
Ryu Shi-Yong
Lee Kang-Ro
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Abstract
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Phytochemical investigation of the MeOH extract of the aerial parts of Bistorta manshuriensis resulted in the isolation of two cerebrosides, two lactams, six phenolic compounds and seven flavonoids. Their chemical structures were characterized by spectroscopic methods to be pinelloside (1), soyacerebroside I (2), pterolactam (3), 5-hydroxypyrrolidine-2-one (4), vanillic acid (5), caffeic acid methyl ester (6), protocatechuic acid (7), caffeic acid (8), 3,5-di-O-caffeoyl quinic acid methyl ester (9), chlorogenic acid methyl ester (10), avicularin (11), afzelin (12), quercetin (13), isoorientin (14), quercetin 3-O-β-D-glucoside (15), quercitrin (16), and luteolin (17). The isolated compounds (1 - 4, 7, 12, 14) were isolated for the first time from this plant source and the compounds 1 - 4, 9 and 10 were first reported from the genus Bistorta. Compound 17 exhibited moderate cytotoxicity and compound 6 exhibited weak cytotoxicity against four human cancer cell lines in vitro using an SRB bioassay.
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KEYWORD
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Bistorta manshuriensis, Polygonaceae, Cerebrosides, Cytotoxicity
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