|
KMID : 0620720090150040250
|
|
Natural Product Sciences
2009 Volume.15 No. 4 p.250 ~ p.255
|
|
|
Cytotoxic Compounds from the Roots of Pulsatilla koreana
|
|
Cuong To Dao
Hung Tran Manh
Lee Mi-Kyoung
Nguyen Thi Phuong Thao
Jang Han-Su
Min Byung-Sun
|
|
|
Abstract
|
|
|
|
Seven compounds including hederagenin 3-[(O-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl) (1), 3β-[(O-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl)oxy]olean-12-en-28-oic acid (2), caffeic acid methyl ester (3), ferulic acid (4), orebiusin A (5), latifonicinin C (6) and 5-(hydroxymethyl)-2-furfuraldehyde (7) were isolated from the ethyl acetate fraction of the roots of Pulsatilla koreana. Their chemical structures were established based on physicochemical and spectroscopic data analyses. All isolates were investigated for their cytotoxic activity against cancer cell lines. Among them, compound 1 showed inhibitory activity against A549, COLO 205, and L1210 cancer cell lines with IC50 values of 15.8, 36.5, and 22.8 μg/mL, respectively.
|
|
|
KEYWORD
|
|
|
Pulsatilla koreana, Ranunculaceae, Cytotoxic activity, Hederagenin glucoside
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|