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KMID : 0620720100160010006
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Natural Product Sciences
2010 Volume.16 No. 1 p.6 ~ p.9
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Isolation of Hepatoprotective Phenylpropanoid from Lactuca indica
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Kim Ki-Hyun
Kim Young-Ho
Lee Kang-Ro
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Abstract
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In continuing our search for biologically active compounds from Korean Compositae medicinal plants, we investigated the constituents of the aerial parts of Lactuca indica L. and isolated a phenylpropanoid derivative from its MeOH extract. The chemical structure was characterized by spectroscopic methods, including 1D and 2D NMR to be di-E-caffeoyl-meso-tartaric acid (1). Compound 1 was isolated for the first time from this plant. In this paper, we suggest that the NMR assignment at C-2 of (+)-taraxafolin-B should be corrected. In the human HBV-transfected liver cell line HepG2.2.15, the compound 1 effectively reduced HBV DNA level in the release of mature HBV particles from HepG2.2.15 cultivation.
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KEYWORD
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Lactuca indica L. Compositae, Di-E-caffeoyl-meso-tartaric acid, Hepatoprotective activity
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