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KMID : 0620720100160020059
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Natural Product Sciences
2010 Volume.16 No. 2 p.59 ~ p.67
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Recent Advances in Anti-inflammatory Synthetic Flavonoids as Potential Drugs
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Kim Hyun-Pyo
Park Hae-Il
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Abstract
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Flavonoids are well-known anti-inflammatory agents that exert their effects via a variety of mechanisms including antioxidative action, inhibition of eicosanoid metabolizing enzymes and regulation of the expression of proinflammatory molecules. In this review, synthetic approaches to obtain more useful flavonoid derivatives are summarized. Human clinical trials of flavonoid therapy are discussed. Through continual investigation to identify more potent and comparable flavonoids, new anti-inflammatory flavonoid therapy will be successfully launched, especially for the treatment of chronic inflammatory disorders.
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KEYWORD
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Synthetic flavonoid, Anti-inflammation, Clinical trial
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