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KMID : 0620720100160020075
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Natural Product Sciences
2010 Volume.16 No. 2 p.75 ~ p.79
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Monoamine Oxidase Inhibitory Flavonoids from the Root Bark of Cudrania tricuspidata
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Xiang Hua Han
Hwang Ji-Hye
Hong Seong-Su
Choe Sang-gil
Lee Chul
Lee Myung-Koo
Lee Mi-Kyeong
Hwang Bang-Yeon
Lee Moon-Soon
Lee Dong-Ho
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Abstract
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Two new benzylated flavonoids, 5,7,4`-trihydroxy-6-p-hydroxybenzylflavanone (1) and 5,7,4`-trihydroxy-6,8-di-p-hydroxybenzylflavanone (2) together with six known flavonoids, kaempferol (3), artocarpesin (4), cycloartocarpesin (5), cudraflavone D (6), gericudranin E (7), and leachianone G (8) have been isolated from the root bark of Cudrania tricuspidata. The structures of 1 and 2 were characterized based on spectroscopic data including 1D-and 2D-NMR. All the isolates were evaluated for their inhibitory effects of monoamine oxidase (MAO). Among them, kaempferol (3), artocarpesin (4), and cudraflavone D (6) showed moderate inhibitory effects with IC50 values of 82.3, 30.8, and 71.8 M, respectively.
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KEYWORD
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Cudrania tricuspidata, Moraceae, Benzylated flavonoid, Monoamine oxidase inhibitor
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