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KMID : 0620720100160020099
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Natural Product Sciences
2010 Volume.16 No. 2 p.99 ~ p.106
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Protection by Methanol Extract of Longan (Dimocarpus Longan Lour.) Peel against Kainic acid-Induced Seizure
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Jo Young-Jun
Cho Hwang-Eui
Lee Mi-Kyeong
Hwang Bang-Yeon
Hong Jin-Tae
Moon Dong-Cheul
Oh Ki-Wan
Eun Jae-Soon
Kim Hyoung-Chun
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Abstract
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This experiment was undertaken to investigate whether methanol extract of fruit peel of Dimocarpus longan Lour. (MEFL) protects against kainic acid (KA)-induced seizure. Oral administration of MEFL (1, 2 and 4 mg/kg) increased KA (50 mg/kg)-induced survival rate and latency of convulsion onset, and deceased seizure scores and weight loss induced by intraperitoneal (i.p) injection of KA in mice. In addition, MEFL protected against cell death in the hippocampus of rat brain after KA-administration as analyzed by using TUNEL assay in rats. MEFL also significantly blocked seizure-form of electroencephalogram (EEG) power spectra induced by KA in rats. MEFL also inhibited elevation of [Ca2+]i and increased [Cl?]i induced by KA in cultured neuronal cells. Therefore, it is suggested that MEFL protects against seizure induced by KA, decreasing [Ca2+]i.
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KEYWORD
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Dimocarpus Longan, Kainic acid, KA, Seizure, Hippocampus, Cell death, [Ca2+]i
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