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KMID : 0620720100160030143
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Natural Product Sciences
2010 Volume.16 No. 3 p.143 ~ p.147
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Inhibitors of Nitric Oxide Production from Artemisia princeps
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Li Da-Yu
Xiang Hua Han
Hong Seong-Su
Lee Chul
Lee Mi-Kyeong
Hwang Bang-Yeon
Lee Dong-Ho
Lee Moon-Soon
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Abstract
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The chromatographic separation of a methanol extract of Artemisia princes led to the isolation of two sesquiterpene lactones, artecanin (1) and canin (2), together with a flavonoid, eupatilin (3). Their structures were determined by 1D, 2D-NMR and MS data analysis. All of the isolates were evaluated for their potential to inhibit the LPS-induced production of nitric oxide in murine macrophage RAW 264.7 cells. Compounds 1-3 inhibited nitric oxide production with IC50 values of 19.5, 20.4 and 25.1 μM, respectively.
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KEYWORD
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Artemisia princeps, Compositae, Sesquiterpene Lactone, Nitric oxide production inhibitor
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