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KMID : 0620720100160030148
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Natural Product Sciences
2010 Volume.16 No. 3 p.148 ~ p.152
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Microbial Metabolism of Yangonin, a Styryl Lactone from Piper methysticum (Kava)
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Kim Ji-Hye
Kim Hyun-Jung
Lee Ik-Soo
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Abstract
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Microbial metabolism studies of yangonin (1), a major styryl lactone from Piper methysticum, have resulted in the production of three hydroxylated metabolites (2-4). The chemical structures of these compounds were elucidated to be 4-methoxy-6-(12-hydroxystyryl)-2-pyrone (2), 4-methoxy-6-(11,12-dihydroxystyryl)-2-pyrone (3), and 4,12-dimethoxy-6-(7,8-dihydroxy-7,8-dihydrostyryl)-2-pyrone (4) on the basis of the chemical and spectroscopic analyses. The compounds 3 and 4 are reported herein as microbial metabolites of yangonin for the first time.
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KEYWORD
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Microbial metabolism, Yangonin, Styryl Lactone, Piper methysticum, Kava
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