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KMID : 0620720100160030153
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Natural Product Sciences
2010 Volume.16 No. 3 p.153 ~ p.158
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Anti inflammatory Activity of Codium fragile in Macrophages Induced by Peptidoglycan
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Han Sin-Hee
Kim Young-Guk
Lee Su-Huan
Park Chung-Berm
Han Seung-Won
Jang Hye-Jin
Lee Hyo-Jeong
Park Seong-Cheol
Kim Hye-Sung
Lee Young-Seob
Kwon Dong-Yeul
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Abstract
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To fine out the anti-inflammatory activities of the C. fragile. and its mechanism were investigated in macrophages induced by Peptidoglycan (PGN). Treatments of macrophages with 100 ug/ml of ethanol extract of Codium fragile (EECF) inhibited PGN-induced IL-6, NO and PGE2 production in a dose-dependent manner as well as expression of iNOS and COX-2. EECF inhibited PGN-induced extracellular signal-regulated kinase (ERK) 1/2, JNK 1/2 and p38 MAPK phosphorylation, which suggests that EECF inhibits IL-6 and NO secretion by blocking MAPKs phosphorylation. These findings may help elucidate the mechanism by which EECF modulates RAW 264.7 cell activation under inflammatory conditions.
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KEYWORD
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Ethanol extract of Codium fragile, EECF, anti-inflammatory activities
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