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KMID : 0620720100160030159
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Natural Product Sciences
2010 Volume.16 No. 3 p.159 ~ p.163
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Anti-inflammatory Activity of Detoxified Bacterial Strains in Wistar Rats
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Tapas Kumar Sur
Biswajit Auddy
Susil Kumar Mitra
Dipak Kumar Sarkar
Dipankar Bhattacharyya
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Abstract
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A mixture of several detoxified bacterial strains (Sterodin(R)) has been studied for anti-inflammatory effect in Wistar rats on carrageenin, dextran and prostaglandin E1 (PGE1) induced edema in acute model and cotton pellet and carrageenin induced sub-acute model, while, Freund`s adjuvant induced chronic model. The bacterial strains showed strong inhibitory activity in acute, sub-acute and chronic models of inflammation. Further, it reduced α1 acid glycoprotein and α2 macroglobulin levels in serum and prostaglandin E2 in inflamed paw. These results indicated that the bacterial strains probably act through prostaglandin mediatory pathways and may be useful in treatment of inflammation.
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KEYWORD
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Bacteria, Inflammation, Prostaglandins, Freund`s complete adjuvant, Glycoprotein, Macroglobulin
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