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KMID : 0620720100160030175
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Natural Product Sciences
2010 Volume.16 No. 3 p.175 ~ p.179
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Anti-Aspergillus Activities of the Ligusticum chuanxiong Essential Oil Alone and in Combination with Antibiotics
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Sim Youn
Shin Seung-won
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Abstract
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The present study aimed to assess the antifungal properties of the essential oil fraction from Ligusticum chuanxiong (Umbelliferae) and its components against five clinically important Aspergillus species. The essential oil fraction was extracted from the underground parts of the plant by steam distillation, and its main components, namely, Z-ligustilide, butylidene phthalide, and p-cresol were isolated by column chromatography. The antifungal activities of the essential oils were evaluated by the broth dilution method. Both the total essential oil fraction of L. chuanxiong and its components showed significant anti-Aspergillus activity against all five tested strains with MICs between 62.5 and 250 ㎍/ml, respectively. In a checkerboard microtiter assay, the combination of antibiotics, itraconazole with the essential oil fraction of L. chuanxiong or its main components exhibited synergistic or additive, and in some cases indifferent, effects against the tested Aspergillus species, resulting in FICIs (fractional inhibiting concentration indices) ranging from 0.12 to 2, while the combination of antibiotics, amphothericin B with L. chuanxiong essential oils mostly showed antagonistic effects.
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KEYWORD
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Aspergillus spp., Ligusticum chuanxiong, essential oils, Z-Ligustilide, butylidene phthalide, itraconazole, p-cresol, amphothericin B, synergism
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