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KMID : 0620720100160040211
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Natural Product Sciences
2010 Volume.16 No. 4 p.211 ~ p.216
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Constituents of Erythrina caffra Stem Bark Grown in Egypt
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Sawsan El Masry
Hala M. Hammoda
Hala H. Zaatout
Maged S. Abdel Kader
Saleh I. Alqasoumi
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Abstract
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A new 3-indolyl propionate alkaloid; (-) abrine (1), was isolated from the alcohol extract of Erythrina caffra stem bark together with the alkaloid (-) hypaphorine (2). Phytochemical investigation of the chloroform extract led to the isolation of one fatty alcohol; 1-octacosanol, isolated for the first time from genus Erythrina, two dienoid alkaloids; erythraline and erysodine, and three isoflavonoids; 3S (+) 2`-O-methylphaseollidinisoflavan (3), (6aR, 11aR)- 3-hydroxy-10-dimethylallyl-9-methoxypterocarpan, known as sandwicensin (4) and 3R (-) erythbidin A (5). It is worth mentioning that this is the first report for the isolation of these isoflavonoids from E. caffra. The absolute configuration of 3S (+) 2`-O-methylphaseollidinisoflavan (3) was not previously reported. The isolated isoflavonoids showed promising antibacterial activity against Staphylococcus aureus.
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KEYWORD
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Erythrina caffra, alkaloids, isoflavanoids, Staphylococcus aureus
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